Antiherpes virus effect of the red marine alga Polysiphonia denudata.
نویسنده
چکیده
The water extract from the red marine alga Polysiphonia denudata (Dillwyn) Kutz. from the Bulgarian Black Sea coast selectively inhibited the reproduction of herpes virus type 1 and type 2 in cell cultures (EC50=8.7 to 47.7 mg/ml) as shown by the reduction of virus-induced cytopathic effect and viral infectivity. The virus-inhibitory effect was dose-related, strain-specific and depended on virus inoculum. The inhibition affected adsorption as well as the intracellular stages of viral replication. The presence of the extract throughout the whole replicative cycle was necessary for the full expression of the antiviral effect. In higher concentrations (MIC90=6.5 mg/ml) the extract exhibited strong extracellular virus inactivating activity.
منابع مشابه
Chemical composition and biological activities of the Black Sea algae Polysiphonia denudata (Dillw.) Kutz. and Polysiphonia denudata f. fragilis (Sperk) Woronich.
The two investigated algae had almost identical sterol composition, but there were significant differences in the composition of the polar components and especially in the composition of the volatiles. P. denudata f. fragilis extracts possessed a stronger biological activity (antibacterial, antifungal and toxicity against Artemia salina). Despite the minute morphological differences between the...
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عنوان ژورنال:
- Zeitschrift fur Naturforschung. C, Journal of biosciences
دوره 55 9-10 شماره
صفحات -
تاریخ انتشار 2000